Solubilizers containing alk(en)yl oligoglycosides and polyol components, and methods of solubilizing using the same

ABSTRACT

Solubilizates containing a water-insoluble substance, an aqueous phase and a solubilizer, wherein the solubilizer comprises (i) an alk(en)yl oligoglycoside; and (ii) a polyol component, are described. Methods of solubilizing water-insoluble substances with combinations of alk(en)yl oligoglycosides and polyol components are also described.

BACKGROUND OF THE INVENTION

Solubilizers are used in the preparation of aqueous andaqueous-alcoholic pseudosolutions (“solubilizates”) of water-insolublesubstances with oil-like behavior such as, for example, essential oilsor vitamins, etc. The dissolution of these substances is attributable totheir solubility being greater in the surfactant micelles than in theaqueous phase. This means that above all surfactants capable of formingmicelles even in low concentrations appear to be particularly suitableas solubilizers [Parf. Kosm. 65, 679 (1984)]. However, surfactants suchas these always contain alkylene oxide chains which is not alwaysdesirable from the marketing perspective.

It is pointed out in this connection that the use of alkyl glucosides asemulsifiers for a range of applications is already prior art. Theemulsifying and dispersing properties of polyglycerolpoly-12-hydroxystearates are the subject of DE-A1 4420516 andDE-A1-19643062. Mixtures of alkyl glucosides and polyglycerolpoly-12-hydroxystearates and their use as emulsifiers are described inDE-A1 19533539. However, the formation of emulsions follows a differentmechanism than solubilization. Accordingly, there is nothing in thesuitability of a substance as an emulsifier to suggest that it wouldalso have solubilizing properties.

The problem addressed by the present invention was therefore to providenew solubilizers for the preparation of solubilizates which would notcontain any alkylene oxide and which would provide performance resultsat least comparable with those of known products.

BRIEF SUMMARY OF THE INVENTION

The present invention includes the use of mixtures of glycosides andpolyol esters as solubilizers for the production of solubilizates.

Accordingly, the present invention relates to the use of detergentmixtures containing

(a) alkyl and/or alkenyl oligoglycosides and

(b) polyol polyhydroxy-12-stearates

as solubilizers for the production of clear solubilizates.

It has surprisingly been found that mixtures of alkyl and/or alkenyloligoglycosides and polyol polyhydroxystearates adapted to one anothercan be cold-mixed with water in any ratio and, in addition, also haveexcellent solubilizing properties. Accordingly, it is now possible inaccordance with the new teaching of the invention to formulate clearpseudosolutions containing essential oils or vitamins which, hitherto,could not be obtained by other methods. This discovery is alsosurprising because the polyol polyhydroxystearates, although havinginterfacially active properties, are still mainly lipophilic incharacter and, accordingly, are immiscible with water in any ratio.

DETAILED DESCRIPTION OF THE INVENTION

Alkyl and/or Alkenyl Olipoalycosides

Alkyl and alkenyl oligoglycosides which form component (a) are knownnonionic surfactants which correspond to formula (I):

R¹O—[G]_(p)  (I)

where R¹ is an alkyl and/or alkenyl group containing 4 to 22 carbonatoms, G is a sugar unit containing 5 or 6 carbon atoms and p is anumber of 1 to 10. They may be obtained by the relevant methods ofpreparative organic chemistry. The overviews presented by Bierman et al.in Starch/Stärke 45, 281(1993), by B. Salka in Cosm. Toil. 108, 89(1993) and by J. Kahre in SÖFW-Journal No. 8, 598 (1995) are cited asrepresentative of the extensive literature available on this subject.

The alkyl and/or alkenyl oligoglycosides may be derived from aldoses orketoses containing 5 or 6 carbon atoms, preferably glucose. Accordingly,the preferred alkyl and/or alkenyl oligoglycosides are alkyl and/oralkenyl oligoglucosides. The index p in general formula (I) indicatesthe degree of oligomerization (DP), i.e. the distribution of mono- andoligoglycosides, and is a number of 1 to 10. Whereas p in a givencompound must always be an integer and, above all, may assume a value of1 to 6, the value p for a certain alkyl oligoglycoside is ananalytically determined calculated quantity which is generally a brokennumber. Alkyl and/or alkenyl oligoglycosides having an average degree ofoligomerization p of 1.1 to 3.0 are preferably used. Alkyl and/oralkenyl oligoglycosides having a degree of oligomerization of less than1.7 and, more particularly, between 1.2 and 1.4 are preferred from theapplicational point of view. The alkyl or alkenyl radical R¹ may bederived from primary alcohols containing 4 to 11 and preferably 8 to 10carbon atoms. Typical examples are butanol, caproic alcohol, caprylicalcohol, capric alcohol and undecyl alcohol and the technical mixturesthereof obtained, for example, in the hydrogenation of technical fattyacid methyl esters or in the hydrogenation of aldehydes from Roelen'soxosynthesis. Alkyl oligoglucosides having a chain length of C₈ to C₁₀(DP=1 to 3), which are obtained as first runnings in the separation oftechnical C₈₋₁₈ coconut oil fatty alcohol by distillation and which maycontain less than 6% by weight of C₁₂ alcohol as an im-purity, and alsoalkyl oligoglucosides based on technical C_(9/11) oxoalcohols (DP=1 to3) are preferred. In addition, the alkyl or alkenyl radical R¹ may alsobe derived from primary alcohols containing 12 to 22 and preferably 12to 14 carbon atoms. Typical examples are lauryl alcohol, myristylalcohol, cetyl alcohol, palmitoleyl alcohol, stearyl alcohol, isostearylalcohol, oleyl alcohol, elaidyl alcohol, petroselinyl alcohol, arachylalcohol, gadoleyl alcohol, behenyl alcohol, erucyl alcohol, brassidylalcohol and technical mixtures thereof which may be obtained asdescribed above. Alkyl oligoglucosides based on hydrogenated C_(12/14)coconut oil fatty alcohol having a DP of 1 to 3 are preferred.

Polyol poly-12-hydroxystearates

The polyol poly-12-hydroxystearates which form component (b) are knownsubstances which are marketed by Henkel KGaA of Düsseldorf, FRG, forexample under the name of “Dehymuls® PGPH”. Reference is also made inthis connection to International patent application WO 95/34528(Henkel). The polyol component of the emulsifiers may be derived fromsubstances which contain at least 2, preferably 3 to 12 and morepreferably 3 to 8 hydroxyl groups and 2 to 12 carbon atoms. Typicalexamples are

(a) glycerol and polyglycerol;

(b) alkylene glycols such as, for example, ethylene glycol, diethyleneglycol, propylene glycol;

(c) methylol compounds such as, in particular, trimethylol ethane,trimethylol propane, trimethylol butane, pentaerythritol anddipentaerythritol;

(d) alkyl oligoglucosides containing 1 to 22, preferably 1 to 8 and morepreferably 1 to 4 carbon atoms in the alkyl group such as, for example,methyl and butyl glucoside;

(e) sugar alcohols containing 5 to 12 carbon atoms such as, for example,sorbitol or mannitol,

(f) sugars containing 5 to 12 carbon atoms such as, for example, glucoseor sucrose;

(g) amino sugars such as, for example, glucamine.

Among the emulsifiers suitable for use in accordance with the invention,reaction products based on polyglycerol are particularly important byvirtue of their excellent applicational properties. It has proved to beof particular advantage to use selected polyglycerols which have thefollowing homolog distribution (the preferred ranges are shown inbrackets):

glycerols  5 to 35 (15 to 30) % by weight diglycerols 15 to 40 (20 to32) % by weight trigiycerols 10 to 35 (15 to 25) % by weighttetraglycerols  5 to 20 (8 to 15) % by weight pentaglycerols  2 to 10 (3to 8) % by weight oligoglycerols to 100 % by weight

Components (a) and (b) may be mixed in a ratio of 10:90 to 90:10,preferably 25:75 to 75:25 and more preferably 40:60 to 60:40. A mixtureof alkyl glucosides and polyglycerol poly-12-hydroxystearate in a ratioby weight of 1:1, which is commercially obtainable as Eumulgin® VL75, isparticularly preferred. The solubilizers can make up from 1 to 25% byweight and preferably from 5 to 15% by weight of the final formulations.

Essential Oils

The substances with oil-like properties which can be solubilized asdescribed above include, for example, the essential oils. These areunderstood by the expert to be perfuming substances which are obtainedfrom plants, plant parts or even spices by physical, preferablydistillation-based, process steps. Essential oils can be distinguishedfrom the known fatty oils by a simple test: they do not leave any fattystains behind on paper. These substances are complex mixtures of partlyreadily volatile alcohols, aldehydes, ketones, esters, lactones, sulfur-and nitrogen-containing compounds and hydrocarbons; most of theodor-determining constituents of essential oils are terpenes andsesquiterpenes. Typical examples of suitable essential oils are theextracts of blossoms (lavender, rose, jasmine, neroli), stems and leaves(geranium, patchouli, petitgrain), fruits (anise, coriander, caraway,juniper), fruit peel (bergamot, lemon, orange), roots (nutmeg, angelica,celery, cardamon, costus, iris, calmus), woods (pinewood, sandalwood,guaiac wood, cedarwood, rosewood), herbs and grasses (tarragon, lemongrass, sage, thyme), needles and branches (spruce, fir, pine, dwarfpine), resins and balsams (galbanum, elemi, benzoin, myrrh, olibanum,opoponax). Suitable synthetic or semisynthetic perfume oils areAmbroxan, eugenol, isoeugenol, citronellal, hydroxycitronellal,geranoil, citronellol, geranyl acetate, citral, ionone and methylionone.

Vitamins

Besides the essential oils, vitamins can also be solubilized by themixtures of alkyl glycosides and polyglycerol esters. Typical examplesare vitamins of the A group (retinol, 3,4-dehydroretinol), the B group(thiamine chloride hydrochloride, riboflavin, pyridoxine, pyridoxamine,pyridoxal, cyanocobalamin, biotin, folic acid, nicotinic acid, nicotinicacid amide, pantothenic acid), the C group (ascorbic acid), the D group(calciferol, ergocalciferol, colecalciferol) and the E group(tocopherols, tocopherol acetates). The essential oils and vitamins maybe used in quantities of 0.1 to 10% by weight and preferably inquantities of 0.5 to 1% by weight, based on the solubilizates.

Auxiliaries and Additives

The solubilizates may be purely aqueous although they may also be madeup as aqueous-alcoholic formulations using ethanol or isopropyl alcohol.Although the mixing ratio with water is not critical, 60 to 70% byweight alcoholic solutions are preferred and may be used, for exampletogether with suitable skin care ingredients, as lotions forimpregnating refreshing towels and as deodorant formulations,aftershaves, eau-de-toilettes and the like.

The solubilizates may also contain mild surfactants, oil components,superfatting agents, stabilizers, consistency factors, thickeners,polymers, silicone compounds, biogenic agents, antidandruff agents, filmformers, preservatives, hydrotropes, solubilizers, UV filters, insectrepellents, self-tanning agents, dyes and the like as furtherauxiliaries and additives.

Typical examples of suitable mild surfactants, i.e. surfactants withparticular dermatological compatibility, are fatty alcohol polyglycolether sulfates, monoglyceride sulfates, mono- and/or dialkylsulfosuccinates, fatty acid isethionates, fatty acid sarcosinates, fattyacid taurides, fatty acid glutamates, ether carboxylic acids, alkyloligoglucosides, fatty acid glucamides, alkylamidobetaines and/orprotein fatty acid condensates, preferably based on wheat proteins.

Suitable oil components are, for example, Guerbet alcohols based onfatty alcohols containing 6 to 18 and preferably 8 to 10 carbon atoms,esters of linear C₆₋₂₂ fatty acids with linear C₆₋₂₂ fatty alcohols,esters of branched C₆₋₁₃ carboxylic acids with linear C₆₋₂₂ fattyalcohols, esters of linear C₆₋₂₂ fatty acids with branched alcohols,more especially 2-ethyl hexanol, esters of linear and/or branched fattyacids with polyhydric alcohols (for example propylene glycol, dimer diolor trimer triol) and/or Guerbet alcohols, triglycerides based on C₆₋₁₀fatty acids, liquid mono-/di-/triglyceride mixtures based on C₆₋₁₈ fattyacids, esters of C₆₋₂₂ fatty alcohols and/or Guerbet alcohols witharomatic carboxylic acids, more especially benzoic acid, esters of C₂₋₁₂dicarboxylic acids with linear or branched alcohols containing 1 to 22carbon atoms or polyols containing 2 to 10 carbon atoms and 2 to 6hydroxyl groups, vegetable oils, branched primary alcohols, substitutedcycloyhexanes, linear C₆₋₂₂ fatty alcohol carbonates, Guerbetcarbonates, esters of benzoic acid with linear and/or branched C₆₋₂₂alcohols (for example Finsolv® TN), dialkyl ethers, ring openingproducts of epoxidized fatty acid esters with polyols, silicone oilsand/or aliphatic or naphthenic hydrocarbons.

The superfatting agents used may be such substances as, for example,lanolin and lecithin and polyethoxylated or acylated lanolin andlecithin derivatives, polyol fatty acid esters, monoglycerides and fattyacid alkanolamides, the latter also serving as foam stabilizers.

Suitable consistency factors are, above all, fatty alcohols containing12 to 22 and preferably 16 to 18 carbon atoms and, in addition, partialglycerides. A combination of these consistency factors with alkyloligoglucosides and/or fatty acid-N-methyl glucamides of the same chainlength and/or polyglycerol poly-12-hydroxystearates is preferred.Suitable thickeners are, for example, polysaccharides, more particularlyxanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethylcellulose and hydroxyethyl cellulose, relatively high molecular weightpolyethylene glycol monoesters and diesters of fatty acids,polyacrylates (for example Carbopols® [Goodrich] or Synthalens®[Sigma]), polyacrylamides, polyvinyl alcohol and polyvinyl pyrrolidone,surfactants such as, for example, ethoxylated fatty acid glycerides,esters of fatty acids with polyols such as, for example, pentaerythritolor trimethylol propane, narrow-range fatty alcohol ethoxylates or alkyloligoglucosides and electrolytes, such as sodium chloride and ammoniumchloride.

Suitable cationic polymers are, for example, cationic cellulosederivatives such as, for example, the quaternized hydroxyethyl celluloseavailable under the name of Polymer JR 400® from Amerchol, cationicstarch, copolymers of diallyl ammonium salts and acrylamides,quaternized vinyl pyrrolidone/vinyl imidazole polymers such as, forexample, Luviquat® (BASF), condensation products of polyglycols andamines, quaternized collagen polypeptides such as, for example,Lauryldimonium Hydroxypropyl Hydrolyzed Collagen (Lamequat®L Grunau),quaternized wheat polypeptides, polyethyleneimine, cationic siliconepolymers such as, for example, Amodimethicone, copolymers of adipic acidand dimethyl aminohydroxypropyl diethylenetriamine (Cartaretine®,Sandoz), copolymers of acrylic acid with dimethyl diallyl ammoniumchloride (Merquat® 550, Chemviron), polyaminopolyamides as described,for example, in FR-A 225840 and crosslinked water-soluble polymersthereof, cationic chitin derivatives such as, for example, quaternizedchitosan, optionally in microcrystalline distribution, condensationproducts of dihaloalkyls such as, for example, dibromobutane withbis-dialkylamines such as, for example, bis-dimethylamino-1,3-propane,cationic guar gum such as, for example, Jaguar® CBS, Jaguar®) C-17,Jaguar® C-16 of Celanese, quaternized ammonium salt polymers such as,for example, Mirapol® A-15, Mirapol® AD-1, Mirapol® AZ-1 of Miranol.

Suitable anionic, zwitterionic, amphoteric and nonionic polymers are,for example, vinyl acetate/crotonic acid copolymers, vinylpyrrolidone/vinyl acrylate copolymers, vinyl acetate/butylmaleate/isobornyl acrylate copolymers, methyl vinylether/maleicanhydride copolymers and esters thereof, uncrosslinked andpolyol-crosslinked polyacrylic acids, acrylamidopropyl trimethylammoniumchloride/acrylate copolymers, octylacrylamide/methylmethacrylate/tert.-butylaminoethyl methacrylate/2-hydroxypropylmethacrylate copolymers, polyvinyl pyrrolidone, vinyl pyrrolidone/vinylacetate copolymers, vinyl pyrrolidone/dimethylaminoethylmethacrylate/vinyl caprolactam terpolymers and optionally derivatizedcellulose ethers and silicones.

Suitable silicone compounds are, for example, dimethyl polysiloxanes,methyl phenyl polysiloxanes, cyclic silicones and amino-, fatty acid-,alcohol-, polyether-, epoxy-, fluorine- and/or alkyl-modifled siliconecompounds which may be both liquid and resin-like at room temperature.Typical examples of fats are glycerides while suitable waxes are interalia beeswax, carnauba wax, candelilla wax, montan wax, paraffin wax ormicrowaxes, optionally in combination with hydrophilic waxes, forexample cetostearyl alcohol, or partial glycerides. Suitable stabilizersare metal salts of fatty acids such as, for example, magnesium,aluminium and/or zinc stearate. Biogenic agents in the context of theinvention are, for example, tocopherol, tocopherol acetate, tocopherolpalmitate, ascorbic acid, deoxyribonucleic acid, retinol, bisabolol,allantoin, phytantriol, panthenol, AHA acids, amino acids, ceramides,pseudoceramides, essential oils, plant extracts and vitamin complexes.Suitable antidandruff agents are climbazol, octopirox and zincpyrithione. Typical film formers are, for example, chitosan,microcrystalline chitosan, quaternized chitosan, polyvinyl pyrrolidone,vinyl pyrrolidone/vinyl acetate copolymers, polymers of the acrylic acidseries, quaternary cellulose derivatives, collagen, hyaluronic acid andsalts thereof and similar compounds. Montmorillonites, clay minerals,Pemulen and alkyl-modified Carbopol types (Goodrich) may be used asswelling agents for aqueous phases.

UV filters in the context of the invention are organic substances whichare capable of absorbing ultraviolet radiation and of releasing theenergy absorbed in the form of longer-wave radiation, for example heat.UV-B filters can be oil-soluble or water-soluble. The following areexamples of oil-soluble substances:

3-benzylidene camphor and derivatives thereof, for example3-(4-methylbenzylidene)-camphor;

4-aminobenzoic acid derivatives, preferably 4-(dimethylaminoibenzoicacid-2-ethylhexyl ester, 4-(dimethylamino)-benzoic acid-2-octyl esterand 4-(dimethylaminoybenzoic acid amyl ester;

esters of cinnamic acid, preferably 4-methoxycinnamic acid-2-ethylhexylester, 4-methoxycinnamic acid isopentyl ester, 2-cyano-3-phenylcinnamicacid-2-ethylhexyl ester (Octocrylene);

esters of salicylic acid, preferably salicylic acid-2-ethylhexyl ester,salicylic acid-4-isopropylbenzyl ester, salicylic acid homomenthylester;

derivatives of benzophenone, preferably 2-hydroxy4-methoxybenzophenone,2-hydroxy-4-methoxy4′-methylbenzophenone,2,2′-dihydroxy-4-methoxybenzophenone;

esters of benzalmalonic acid, preferably 4-methoxybenzalmalonic aciddi-2-ethylhexyl ester;

triazine derivatives such as, for example,2,4,6-trianilino-(p-carbo-2′-ethyl-1′-hexyloxy)-1,3,5-triazine and OctylTriazone;

propane-1,3-diones such as, for example,1-(4-tert.butylphenyl>3-(4′-methoxyphenylypropane-1,3-dione;

Suitable water-soluble substances are

2-phenylbenzimidazole-5-sulfonic acid and alkali metal, alkaline earthmetal, ammonium, alkylammonium, alkanolammonium and glucammonium saltsthereof;

sulfonic acid derivatives of benzophehones, preferably2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and salts thereof;

sulfonic acid derivatives of 3-benzylidene camphor such as, for example,4-(2-oxo-3-bornylidenemethyl)-benzene sulfonic acid and2-methyl-5-(2-oxo-3-bornylidene)-sulfonic acid and salts thereof.

Typical UV-A filters are, in particular, derivatives of benzoyl methanesuch as, for example,1-(4′-tert.butylphenyl)-3-(4′-methoxyphenyl)-propane-1,3-dione or1-phenyl-3-(4′-isopropylphenyl)-propane-1,3-dione. The UV-A and UV-Bfilters may of course also be used in the form of mixtures. Besides thesoluble substances mentioned, insoluble pigments, i.e. finely dispersedmetal oxides or salts, for example titanium dioxide, zinc oxide, ironoxide, aluminium oxide, cerium oxide, zirconium oxide, silicates(talcum), barium sulfate. and zinc stearate, may also be used for thispurpose. The particles should have a mean diameter of less than 100 nm,preferably between 5 and 50. nm and more preferably between 15 and 30nm. They may be spherical in shape although ellipsoidal particles orother non-spherical particles may also be used. Besides the two groupsof primary UV filters mentioned above, secondary UV filters of theantioxidant type may also be used. Secondary UV filters of theantioxidant type interrupt the photochemical reaction chain which isinitiated when UV rays penetrate into the skin. Typical examples areSuperoxid-Dismutase, tocopherols (vitamin E) and ascorbic acid (vitaminC). Other suitable UV filters can be found in P. Finkel's review inSÖFW-Journal 122, 543 (1996).

In addition, hydrotropes such as, for example, ethanol, isopropylalcohol or polyols may be used to improve flow behavior. Suitablepolyols preferably contain 2 to 15 carbon atoms and at least twohydroxyl groups. Typical examples are

glycerol;

alkylene glycols such as, for example, ethylene glycol, diethyleneglycol, propylene glycol, butylene glycol, hexylene glycol andpolyethylene glycols having an average molecular weight of 100 to 1,000dalton;

technical oligoglycerol mixtures with a degree of self-condensation of1.5 to 10 such as, for example, technical diglycerol mixtures with adiglycerol content of 40 to 50% by weight;

methylol compounds such as, in particular, trimethylol ethane,trimethylol propane, trimethylol butane, pentaerythritol anddipentaerythritol;

lower alkyl glucosides, particularly those containing 1 to 8 carbonatoms in the alkyl group, for example methyl and butyl glucoside;

sugar alcohols containing 5 to 12 carbon atoms such as, for example,sorbitol or mannitol;

sugars containing 5 to 12 carbon atoms such as, for example, glucose orsucrose and

aminosugars such as, for example, glucamine.

Suitable preservatives are, for example, phenoxyethanol, formalde-hydesolution, parabens, pentanediol or sorbic acid. Suitable insectrepellents are N,N-diethyl-m-toluamide, pentane-1,2-diol or InsectRepellent 3535. A suitable self-tanning agent is dihydroxyacetone.

Suitable dyes are any of the substances suitable and approved forcosmetic purposes as listed, for example, in the publication“Kosmetische Färbemittel” of the Farbstoffkommission der DeutschenForschungs-gemeinschaft, Verlag Chemie, Weinheim, 1984, pages 81 to 106,These dyes are normally used in concentrations of 0.001 to 0.1% byweight, based on the mixture as a whole.

EXAMPLES

Lavender oil was stirred in a quantity of 1% by weight into aqueoussolutions of various solubilizers. The results are set out in Table 1.Example 1 correspond to the invention while Examples C1 and C2 areintended for comparison.

TABLE 1 Solubilization of lavender oil (quantities in % by weight)Composition/evaluation 1 C1 C2 Lavender oil 1.0 1.0 1.0 Polyglyceryl-25.0 — — Dipolyhydroxystearate (and) Lauryglucoside* Polyglyceryl-2 — 5.0— Dipolyhydroxystearate Laurylglucoside — — 5.0 Water to 100 EvaluationClear Separates, Separates, solubilizate cloudy cloudy *Ratio by weight1:1

Further exemplary formulations are shown in Table 2 where formulations(A) to (C) are impregnating liquids for cleaning cloths, (D) is adeodorant formulation, (E) is an eau-de-toilette and (F) is anaftershave.

TABLE 2 Exemplary formulations Composition A B C D E F Polyglyceryl-29.7 12.5 9.0 10.0 14.8 12.5 Dipolyhydroxystearate (and) LaurylglucosideTriethyl citrate — — — 2.0 — — Coco Glycerides 0.5 — — — — — Lavenderoil 0.3 — 0.5 1.0 5.0 2.0 Bergamot oil — 1.5 — — — — Isoamylp-Methoxycinnamate — — — — — 0.2 Dimethicon Copoyol — — 1.0 1.0 — 1.0Ethanol — — — 10.0 — 10.0 Methyl paraben 0.2 0.2 0.2 0.2 0.2 0.2Carbomer (+ KOH, pH 5.5) — — 0.05 — — — Panthenol 1.0 1.0 1.0 — — 1.0Bisabolol — 0.2 0.2 — — — Water to 100

What is claimed is:
 1. A method of solubilizing a water-insolublesubstance in an aqueous phase, said method comprising: (a) providing asolubilizer comprising (i) an alk(en)yl oligoglycoside; and (ii) apolyol component; (b) combining the solubilizer with at least onewater-insoluble substance and an aqueous phase.
 2. The method accordingto claim 1, wherein the polyol component comprises a polyolpolyhydroxystearate.
 3. The method according to claim 1, wherein thepolyol component comprises a polyglycerol polyhydroxystearate.
 4. Themethod according to claim 1, wherein the alk(en)yl oligoglycosidecorresponds to the general formula (I): R¹O—[G]_(p)  (I) wherein R¹represents an alk(en)yl radical having from about 4 to about 22 carbonatoms, G represents a sugar residue having from about 5 to about 6carbon atoms and p is a number of from about 1 to about
 10. 5. Themethod according to claim 1, wherein the polyol component comprises apolyglycerol polyhydroxystearate, and wherein the alk(en)yloligoglycoside corresponds to the general formula (I): R¹O—[G]_(p)  (I)wherein R¹ represents an alk(en)yl radical having from about 4 to about22 carbon atoms, G represents a sugar residue having from about 5 toabout 6 carbon atoms and p is a number of from about 1 to about
 10. 6.The method according to claim 1, wherein the solubilizer comprisespolyglycerol-2-dipolyhydroxystearate and laurylglucoside.
 7. The methodaccording to claim 1, wherein the alk(en)yl oligoglycoside and thepolyol component are present in a weight ratio of from about 10:90 toabout 90:10.
 8. The method according to claim 5, wherein the alk(en)yloligoglycoside and the polyglycerol polyhydroxystearate are present in aweight ratio of from about 10:90to about 90:10.
 9. The method accordingto claim 6, wherein the laurylglucoside and thepolyglycerol-2-dipolyhydroxystearate are present in a weight ratio offrom about 10:90 to about 90:10.
 10. The method according to claim 1,wherein the solubilizer is present in an amount of from about 1 to about25% by weight, based on the total weight of the solubilizate.
 11. Themethod according to claim 1, wherein the water-insoluble Lsubstancecomprises at least one component selected from the group consisting ofessential oils and vitamins.
 12. The method according to claim 1,wherein the at least one water-insoluble substance is present in anamount of from about 0.1 to about 10% by weight, based on the totalweight of the solubilizate.